Cytogenetic characterization of tenosynovial giant cell tumors (nodular tenosynovitis).
نویسندگان
چکیده
Chromosome investigation in six localized forms of tenosynovial giant cell tumors, also known as modular tenosynovitis, revealed an identical translocation between chromosomes 1 and 2, t(1;2)(p11;q35-36) in three tumors, a variant translocation t(1;5)(p11;q22) in a fourth case, and a t(2;16)(q33;q24) in a fifth case. One case showed a normal karyotype. Although morphologically rather uniform, these benign tumors appear to be cytogenetically heterogeneous, but the chromosome changes seem to cluster in 2 regions, 1p11 and 16q24.
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ورودعنوان ژورنال:
- Cancer research
دوره 54 15 شماره
صفحات -
تاریخ انتشار 1994